Irinel Popescu


1999–2016 2018
1992–1995 1983–1992
Irinel Popescu
Domnita Ruxandra, no.30, ap.2, 020562 Bucharest (Romania)
Work phone: +40213180417
Head of “Dan Setlacec” Center of General Surgery and Liver Transplantation Fundeni Clinical Institute, Bucharest (Romania)
Professor of Surgery
Titu Maiorescu University, Faculty of Medicine
Professor of Surgery, Faculty of Medicine
“Carol Davila” University of Medicine and Pharmacy, Bucharest (Romania)
President of Romanian Academy of Medical Sciences Romanian Academy of Medical Sciences, Bucharest (Romania)
Associate Professor
“Carol Davila” University of Medicine and Pharmacy, Bucharest (Romania)
“Carol Davila” University of Medicine and Pharmacy, Bucharest (Romania) Assistant professor
“Carol Davila” University of Medicine and Pharmacy, Bucharest (Romania)
“Carol Davila” University of Medicine and Pharmacy, Bucharest (Romania) General medicine
Fundeni Clinical Institute, Bucharest (Romania)
Irinel Popescu
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Postgraduate training in liver surgery and liver transplantation Hôpital Paul-Brousse, Paris (France)
“Carol Davila” University of Medicine and Pharmacy, Bucharest (Romania)
Title of the doctoral thesis: “Acute Hemorrhagic Gastric Ulcerations” Leader – Prof. Dr. Dan Setlacec
Postgraduate training in liver surgery and liver transplantation Charite Hospital, Berlin (Germany)
Certificate of Competence in laparoscopic surgery
Ministry of Health / National Training Center, Bucharest (Romania)
Research Fellow: Liver Transplantation Division
Liver Transplantation Division- The Mount Sinai Hospital, New York (United States)
Research Fellow: Liver Transplantation Dept University of Pittsburgh, Pennsylvania (United States)
Postgraduate training in liver surgery and liver transplantation
Liver Transplantation Dept.-University of Pittsburg, Pennsylvania (United States)
Personal contributions:

In2000livertransplantasatherapeuticmethodinRomaniawasintroduced.Today,livertransplantprograminRomaniais presented as one of the most valuable in Europe, with a total of 913 liver transplants, in terms of survival, with similar results of international centers.
In2014theestablishmentofthesecondlivertransplantcenteratSt.Mary’sHospitalwherewasperformed34liver transplants so far.
Internationallyrecognizedcontributionsinpancreassurgery(posteriorapproachandtotalresectionofmesopancreasin pancreatic head cancer) published in journals: Hepatogastroenterology, European Journal of Surgical Oncology and Langenbeck’s Archives of Surgery;
Certificate of specialization in esophageal surgery, oncologic surgery, liver surgery and liver transplantation
Ministry of Health / National Training Center, Bucharest (Romania)
Irinel Popescu

appeared in 2012 in Elsevier under the coordination of Prof. Vijay Khatri (University of California, Davis School of Medicine, Sacramento, USA)
▪ EstablishmentofaMyasteniagravissurgeryprogram,theresultsofwhichwerepublishedinthejournalAnnalsofSurgery, the most prestigious journal in the field of surgery in the world. Among the outstanding achievements in the medical field mention the introduction of robotic surgery in Romania, acquiring significant experience (1,000 surgeries).
Contributing to the development of translational research:
▪ Inthefieldoflivertransplantation-publishingarticleswithoriginaltechniques,someofthembeingfirstsforRomaniaor internationally. Mentioned liver transplantation divided (a liver for 2 receivers) and Transplantation “dual graft” (2 fragments of liver to a recipient). Article domino liver transplant in familial hypercholesterolemia worked with the team Acad Simonescu Maya was published in the prestigious journal transplantation: Transplantation. Subsequently, two other articles on the same topic were published in Clinical Transplantation and Liver Transplantation in. It has been shown in these articles, for the first time in the world, the possibility of using liver with familial hypercholesterolemia from another patient. The father of liver transplantation, Thomas Starzl, consider these works as “among the most illuminating in all medical literature.”
▪ Indigestiveoncology-promotingtheconceptof”translationalresearch”basedonatotalof1,500oncologysurgeriesannually performed at “Dan Setlacec” Center of General Surgery and Liver Transplantation.
▪ Basicsofaresearchinfrastructurecapableofidentifyingchangesingenomicandproteomicofdigestivecancers.In2002,it was established biobanks, then genomics and proteomics laboratory and the laboratory of cellular therapies. In 2013 was started the construction of CEMT (Centre of Excellence in Translational Medicine) in Fundeni, with European funds (European Fund of Regional Development POS-CCE).
▪ TheentireresearchactivityofthecenterheadedbyProfessorIrinelPopescuispresentedinscientometricterms,inthearticle “Cercetarea Translationala: O evaluare scientometrica a Centrului de Chirurgie si Transplant Hepatic Fundeni” published in the journal Politica Stiintei si Scientometriei, vol. 2, no .3, in September. 2013 pp. 197-208.
Irinel Popescu
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National and international scientific societies:

RomanianSocietyofSurgery-president2006-2008 Romtransplant(RomanianAssociationofTransplantation:President1998-present)
RomanianSocietyofEndoscopicSurgeryandothersurgicaltechniques(ARCE):President2002- 2006
PresidentoftheRomanianAssociationofHepato‐Biliary‐PancreaticSurgeryandLiver Transplantation (2006 – 2017).
MemberofExecutiveCommittee”InternationalAssociationofSurgeonsandGastroenterologists” (IASG), from 2002
FellowofAmericanCollegeofSurgeons,(FACS)(2005) EuropeanSurgicalAssociation-member(2018-2019president)
EuropeanBoardofSurgery-Transplantsubspecialty(2009)andHepato-Bilio-Pancreaticsurgery (2013)
EuropeanSocietyofOrganTransplantation-member Vice-president-FederationofEuropeanAcademiesofMedicine(FEAM)(May2014-April2017)
Honors and Prizes

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Editorial Activities

BritishJournalofSurgeryLecture:Borel-Staehelin-Lecture:Howtoincreasethenumberofdonors in a liver transplant program) at University of Zurich ( Nov.2014)
Co-Editor-in-Chief,”Archivesdel’UnionMedicaleBalkanique”(“ArchivesoftheBalkanMedical Union”) (1997-present)
MemberoftheEditorialBoard,”JournalofTelemedicineandE-Health” MemberoftheEditorialBoard,”TheOpenTransplantationJournal” MemberoftheEditorialBoard,”BulgarianJournalofVisceralSurgery”(2004)
• European Congress of Coloproctology: Metastatic CRC – what about the primary? – (Vienna, 2012)
National and international scientific cooperation
▪ CorrespondingmemberoftheRomanianAcademy(2013)
▪ MemberofRomanianAcademyofScientists(AOSR)-PresidentoftheMedicalSection
▪ HonorarymemberofAcademyofScienceinMoldova(2007)
▪ Membrecorrespondantétranger-AcadémieNationaledeMédecineFrance(2013)
▪ MembreAssocieétranger-AcadémieNationaledeChirurgie(2003)
“Doctor Honoris Causa”
▪ “Ovidius”University,Constanta,Romania
▪ UniversityofMedicineandPharmacyCraiova,Romania(2006)
▪ UniversityofMedicineandPharmacy”IuliuHaţieganu”,Cluj,Romania(2012)
▪ UniversityofMedicineandPharmacy”NicolaeTestemitanu”Chisinau,RepublicofMoldova Visiting Professor (selection)
▪ KarolinskaUniversityinStockholm(2010)
Keynote speaker (selection)
• •

British Journal of Surgery Lecture: Borel-Staehelin-Lecture: How to increase the number of donors in a liver transplant program) – University of Zurich 2014
Grand Rounds AKH – “The surgical treatment of the metastatic colo-rectal cancer” (Vienna 2015,
The 11th International Minimal Invasive Surgery Symposium and 7th CME Course of
Irinel Popescu

Organisational / managerial skills
IASGO, Seoul National University Bundang Hospital, Korea June 30 – July 1, 2017. The robotic approach in rectal cancer: does it offer a better quality of life?”
• 1ST Congress of The Hungarian Surgical Society Surgical Oncology Sections – 23- 25 March 2017, Seghedin, Ungaria.
• 10th EFR – EuropeanFederation for coloRectal Cancer Congress, April 20 – 22, 2017 at the Medical University of Vienna-” Robotic surgery for rectal cancer: A single center experience
• “Central pancreatectomy” (Feb. 2015) at Universitätsklinikum Hamburg-Eppendorf Research projects
Principal investigator in over 20 clinical studies and coordinator of over 30 research projects, among which CEMT (Center of excellence in translational medicine) project, budget: approx. 10 million euros (European funding)
President of two IASGO (International Association of Surgeons, Gastroenterologists and Oncologists) World Congresses held in Bucharest in 2007 and 2013.
Organizer of Federation of European Academies of Medicine (FEAM) Spring Conference, Bucharest 2014 hosted by the Romanian Academy of Medical Sciences.
Doctoral and postdoctoral education :
▪ 20doctoralthesiscompleted
▪ CoordinatorforTrainingPrograms(doctoral,post-doctoral)inthe”GeorgeEmilPalade”Platform
for Interdisciplinary Training and Research in Translational Medicine ▪ Trainerinpostdoctoralfellowshipsprojects:
“Supporting postdoctoral research for reconstructive surgery transplantation (Postdoc-Transplant) coordinated by Carol Davila University of medicine”Molecular biotechnology for medical applications” coordinated by Institute of Biochemistry – Romanian Academy
Projects: Project Title
Irinel Popescu
Project HEPMARK, 4SEE/30.06.2014 ; Title “Hepatocellular carcinoma stratification based on noninvasive markers” ; Project funded under the “Research in Priority Areas” Program, Financial Mechanism of the European Economic Area (EEA)
The major goal of the project “Hepatocellular carcinoma stratification based on noninvasive markers” (HEPMARK) in accordance with the EEA Research Programme objectives is to stimulate multidisciplinary research by creating and supporting a network for translational science that brings together scientists from Romania, Norway and France.
HEPMARK proposes a concept of research that would identify using expression miRNAs expression, a high-risk group of patients with liver cancer who may develop intrahepatic recurrence/ distant metastasis.
Title project ”Autologous cell replacement therapy for diabetic patients by liver cells transdifferentiation” (Dia-cure,) POC2015:P_37_794,fundedfrom Competitiveness Operational Programme 2014- 2020 Priority Axis 1 – Research, Technological Development and Innovation (Rd&I) To Support Economic Competitiveness and Business
The project relates to the national priority area – HEALTH, having as major objective to establish a core of excellence in applying the process of transdifferentiation for autologous cell therapy of diabetes mellitus, one of the major causes of morbidity and mortality in Romania and worldwide.
The strategic objectives of the project are:
1) To create a nationally and internationally recognized Center of excellence, to enhance the RD capacity and Romanian participation in diabetes research area at
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Irinel Popescu
Development, Action 1.1.4. Attracting high-level personnel from abroad in order to enhance the RD capacity POC-A.1-A.1.1.4-E-2015.
European level
2) Integration of our Romanian groups, coordinated by a high-level international scientist, into a strong network with proficiency in translational research in the field of diabetes research
3) To provide a stimulating environment for the training of research and clinical trainees, including medical students, doctoral students, postdoctoral fellows, residents and fellows from all healthcare professions.
4) To develop tools and technologies and use transdifferentiated liver cells engineered to produce and secrete insulin
Project no. 951, SMIS-CSNR code 14056, “CENTER OF EXCELLENCE IN TRANSLATIONAL MEDICINE”. Fundeni Clinical Institute; Financing: EFRD, by POS CCE (2012- 2015)
“The project falls within the category of large projects within the existing public research institutions which expand their field of activity and at the same time open new research directions in two of the priority areas included in the National Strategy for Research, Development and Innovation 2007-2013: Health and Biotechnology.
”Developing Transplant Competencies”-DCT ; beneficiary- Academy of Health Sciences; Funding : Priority Axis 3 “Increasing adaptability of workers and enterprises”, Key Area of Intervention 3.2 “Training and support for enterprises and employees to promote adaptability” Project duration: 12 months (January – December 2015).
Specific objectives: OS1. Training of a minimum of 921 doctors and 1420 nurses performing specialty areas (organ transplantation, transplantation immunology, cellular therapies) and the use of modern innovative training tools (e-learning technologies) in order to improve medical knowledge; OS2. Promoting the benefits of professional training among 1,000 physicians and 2000 nurses through information campaigns and awareness of the importance of organ, tissue and cell transplantation; OS3. Promoting the importance of the act of donation among the population through information and awareness campaigns organized at national level; OS4. Formation of a national pilot center for simulation in advanced organ and cell transplantation technologies (advanced surgical technologies, hepatic failure, interventional radiology).
Results: Training of 921 physicians and 1518 nurses in highly specialized areas (organ transplantation, transplantation immunology, cellular therapies) and the use of modern innovative training tools (e-learning technologies) to improve the knowledge medical.
Specialization for performance, efficiency and response in organ transplantation – S.P.E.R. POSDRU/81/3.2/S/59616SPERisaproject co-financed by the European Social Fund through the “Sectoral Operational Program for Human Resources Development 2007-2013”
Objective: Opening new perspectives in the field of organ transplantation.
10.05.1999-31.12.2002 ORIZONT 2000 Project – ANSTI
10.05.1999-31.12.2003 C.N.C.S.I.S.
26.08.2002-01.06 1.10.2001-1.07.2004
10.10.2005- 01.04.2008 CEEX – Module I- 56/2005
Project title
Molecular Biology of Transplantation: research of the action mechanism of immunosuppressive drugs
Surgical Techniques and Methods of Suppressing the Immune System in Patients with Hepatic Transplant
CenterofExcellenceforSpaceApplicationsinMedicineand increasingthequalityoflife Demonstrative pilot study of telemedicine for diagnosis, clinical and educational applications
Biomarkers and genic expression profile study correlated with clinico-pathological parameters in pancreatic cancer Acronym GENOPACT
10.05.1999-31.12.2002 ORIZONT 2000 Project – ANSTI Medical Science Academy
Study of malignant characters in different liver tumors
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Irinel Popescu
10.10.2005- 56/2005
10.09.2006- -62/2006
10.09.2006- -63/2006
10.09.2006- III -211/2006
10.09.2006- -64/2006
10.09.2006- -65/2006
01.04.2008 CEEX – Module I- 15.09.2008 CEEX – Module I 15.09.2008 CEEX – Module I 15.09.2008 CEEX – Module 15.09.2008 CEEX – Module I 15.09.2008 CEEX – Module I
Biomolecular studies for prognostic factors in gastrointestinal stromal tumors, Acronym: BISTRO
Genic profiles induced by transcriptional suppression of Ets-1 in pancreatic cancer (PACAGENTER)
Pulmonary preservation with perfluorocarbon in liver transplantation. Acronym: KYOX
Promoting Romanian participation in FP7 European projects in the field of Diabetes Immunogenetics and Pancreatic Beta Regenerative Medicine
Caveolin expression 1, 2 and 3 in pancreatic cancers; Molecular targets in diagnosis and treatment; Acronym: CAVEEX
The therapeutic potential of hematopoietic stem cells in hepatic diseases; Acronym: LIVERSTEM
Immunohistochemical markers for diagnosis and prognosis in primitive and secondary liver tumors; Acronym: IHHP
Proiect CNCSIS type A – 799/2006
Role of S100A4 and MAP4K4 in pancreatic ductal adenocarcinoma progression” PNII-PT-PCCA 90/2012 – The Executive Agency for Higher Education, Research, Development & Innovation Funding, Romania (UEFISCDI)
The project aims in setting-up a partnership in a priority research field – cancer genomics – to identify new molecular mechanisms involved in PDAC progression and design new therapeutic approaches targeting these pathways.

the national and international projects was succesfully finished with results published in prestigious journals such as: Nature Genetics, Hepatogastroenterology, Cancer Gene Therapy, Hepatology, Nature Medicine, Cell. The paper “Combined Gene Expression Analysis of Whole-Tissue and Microdissected Pancreatic Ductal Adenocarcinoma identifies Genes Specifically Overexpressed in Tumor Epithelia”. Hepatogastroenterology. 2008; 55(88): 2016-27 was cited in journals with high IF as: Nature Medicine (2011) – IF: 22.864; Nature (2013) – IF: 38,597; Cell (2012) – ( 2016) – IF:31,957 One of the main interest of Prof. Popescu is research in the field of cholangiocarcinoma and bile duct carcinoma as reflected by 2 published in Nature Genetics. (Nat Genet. 2013; 45(12):1474-8. and Nat. Gen. 1470-3.) He was part of the team of scientists from the National Cancer Centre Singapore, Duke-NUS Graduate Medical School Singapore, Fundeni Clinical Institute and Koen Kaen University (Thailand) that have made a seminal breakthrough in understanding the molecular basis of bile duct cancer or cholangiocarcinoma. His international visibility in the field of poposal is demonstrated by the scientometric data: Publications 232 in ISI Web of Science Core Collection; h-index 29.
– Researcher ID:; Sum of the time cited is 2812 (ISI Web of Science Core Collection);
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Irinel Popescu
SELECTED PAPERS – Web of Science Core Collection
Article title Times Citated
Domino Liver Transplantation: How Far Can We Push the Paradigm? Popescu I, Dima SO. 32 Liver Transpl. 2012 Jan;18(1):22-8. doi: 10.1002/lt.22443.
Factor Year impact
3.944 2012
Total mesopancreas excision in pancreatic head adenocarcinoma: The same impact as total mesorectal excision in rectal carcinoma? Comment on article surgical technique and results of total mesopancreas excision in pancreatic tumours by Adham M and Singhirunnusorn J, Dumitrascu T, Popescu I. Eur J Surg Oncol. 2012 Aug;38(8):725; author reply 726. doi: 10.1016/j.ejso.2012.04.001,
Can hepatic resection provide a long-term cure for patients with intrahepatic cholangiocarcinoma? Spolverato G, Vitale A, Cucchetti A, Popescu I, Marques HP, Aldrighetti L, Gamblin TC, Maithel SK, Sandroussi C, Bauer TW, Shen F, Poultsides GA, Marsh JW, Pawlik TM. Cancer. 2015;121(22):3998-4006
Pseudogene INTS6P1 regulates its cognate gene INTS6 through competitive binding of miR- 17-5p in hepatocellular carcinoma. Peng H, Ishida M, Li L, Saito A, Kamiya A, Hamilton JP, Fu R, Olaru AV, An F, Popescu I, Iacob R, Dima S, Alexandrescu ST, Grigorie R, Nastase A, Berindan-Neagoe I, Tomuleasa C, Graur F, Zaharia F, Torbenson MS, Mezey E, Lu M, Selaru FM. Oncotarget. 2015 Mar 20; 6(8):5666-77
Management of Biliary Cystic Tumors: A Multi-institutional Analysis of a Rare Liver Tumor. Arnaoutakis DJ, Kim Y, Pulitano C, Zaydfudim V, Squires MH, Kooby D, Groeschl R, Alexandrescu S, Bauer TW, Bloomston M, Soares K, Marques H, Gamblin TC, Popescu I, Adams R, Nagorney D, Barroso E, Maithel SK, Crawford M, Sandroussi C, Marsh W, Pawlik TM. Ann Surg. 2015 Feb; 261(2):361-367
MicroRNA down-regulated in human cholangiocarcinoma control cell cycle through multiple targets involved in the G1/S checkpoint. Olaru AV, Ghiaur G, Yamanaka S, Luvsanjav D, An F, Popescu I, Alexandrescu S, Allen S, Pawlik TM, Torbenson M, Georgiades C, Roberts LR, Gores GJ, Ferguson-Smith A, Almeida MI, Calin GA, Mezey E, Selaru FM. Hepatology. 2011 Dec;54(6):2089-98
Intrahepatic cholangiocarcinoma: an international multi-institutional analysis of prognostic factors and lymph node assessment. de Jong MC, Nathan H, Sotiropoulos GC, Paul A, Alexandrescu S, Marques H, Pulitano C, Barroso E, Clary BM, Aldrighetti L, Ferrone CR, Zhu AX, Bauer TW, Walters DM, Gamblin TC, Nguyen KT, Turley R, Popescu I, Hubert C, Meyer S, Schulick RD, Choti MA, Gigot JF, Mentha G, Pawlik TM. J Clin Oncol. 2011 Aug 10;29(23):3140-5. Epub 2011 Jul 5.
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A randomized, double-blind study of the effects of omega-3 fatty acids (Omegaven) on outcome 6 after major liver resection. Linecker M, Limani P, Botea F, Popescu I, Alikhanov R, Efanov M,
Kim P, Khatkov I, Raptis DA, Tschuor C, Beck-Schimmer B, Bonvini J, Wirsching A, Kron P, Slankamenac K, Humar B, Graf R, Petrowsky H, Clavien PA. BMC Gastroenterol. 2015;15:102
2.37 2015
Irinel Popescu
Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection- related bile duct cancers. Chan-On W, Nairismägi ML, Ong CK, Lim WK, Dima S, Pairojkul C, Lim KH, McPherson JR, Cutcutache I, Heng HL, Ooi L, Chung A, Chow P, Cheow PC, Lee SY, Choo SP, Tan IB, Duda D, Nastase A, Myint SS, Wong BH, Gan A, Rajasegaran V, Ng CC, Nagarajan S, Jusakul A, Zhang S, Vohra P, Yu W, Huang D, Sithithaworn P, Yongvanit P, Wongkham S, Khuntikeo N, Bhudhisawasdi V, Popescu I, Rozen SG, Tan P, Teh BT. Nat Genet. 2013 Dec; 45(12):1474-8.
Exome seqencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarc. Jiao, Y., T.M. Pawlik, R.A. Anders, Selaru FM, M.M. Streppel, D.J. Lucas, N. Niknafs,V.B. Guthrie, A. Maitra, P. Argani, G.J. Offerhaus, J.C. Roa, L.R. Roberts, G.J. Gores, I.Popescu, Alexandrescu ST, Dima S, Fassan M, Simbolo M, Mafficini A, Capelli P, Lawlor RT, Ruzzenente A, Guglielmi A, Tortora G, de Braud F, Scarpa A, Jarnagin W, Klimstra D, Karchin R, Velculescu VE, Hruban RH, Vogelstein B, Kinzler KW, Papadopoulos N, Wood LD. Nat Genet, 2013 Dec, 45(12):1470-3.
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